منابع مشابه
Apolipoprotein E and familial longevity.
Exceptional longevity is associated with substantial heritability. The ε4 allele in apolipoprotein E and the linked G allele in rs2075650 of TOMM40 have been associated with increased mortality and the ε2 allele with decreased mortality, although inconsistently. Offspring from long-lived families and spouse controls were recruited at 3 sites in the United States and Denmark. We used generalized...
متن کاملApolipoprotein E and longevity: the Rotterdam Study.
was detected, most of their patients required prednisone treatment after thymectomy. In fact, they showed the remission rate to be 40% in younger patients, but 8% in older patients. 5 Considering these observations together, we emphasize that the prognosis after thymectomy in older patients is not as good as in younger patients, and that their clinical features constitute a particular challenge...
متن کاملmRNA and apolipoprotein E synthesis abnormalities in peripheral blood monocyte macrophages in familial apolipoprotein E deficiency.
We have studied synthesis of apolipoprotein E (apo-E) and apo-E mRNA in cultures of peripheral blood human monocyte macrophages (M-M cultures) obtained from a patient with familial apolipoprotein E deficiency. We have found that the M-M cultures of the apo-E-deficient patients contained two apo-E mRNA species with slightly different molecular weight as compared to normal apo-E mRNA. The apo-E m...
متن کاملApolipoprotein E polymorphism and heterozygous familial hypercholesterolemia. Sex-specific effects.
The impact of apolipoprotein (apo) E polymorphism on interindividual variation in plasma lipid, lipoprotein, and apolipoprotein levels was studied in a sample of familial hypercholesterolemic (FH) patients (147 women, 116 men) with the same mutation, a > 10-kilobase deletion of the low-density lipoprotein (LDL) receptor gene. Each trait was adjusted for concomitants (age, age squared, height, w...
متن کاملPlasma lipoprotein distribution of apolipoprotein E in familial hypercholesterolemia.
Although familial hypercholesterolemia (FH) has been well characterized in terms of the etiology of the major lipoprotein abnormality, that of low density lipoproteins (LDL), less information is available on changes in other lipoproteins which could influence the atherogenic process in this disorder. The present study has focused on such potential abnormalities by studying in detail the lipopro...
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ژورنال
عنوان ژورنال: Neurobiology of Aging
سال: 2013
ISSN: 0197-4580
DOI: 10.1016/j.neurobiolaging.2012.08.019